NBP2-34718-0.1 mg

antibody from Novus Biologicals

Targeting: CDKN1B KIP1, P27KIP1

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

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Validation data

Product number: NBP2-34718-0.1 mg - Provider product page
Provider: Novus Biologicals
Product name: Mouse Monoclonal p27/Kip1 Antibody
Antibody type: Monoclonal
Description: Protein A purified. This MAb recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1, ZR75-30, MCF-7, MDAMB453, T47D, CAL51, 734B), the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.
Reactivity: Human, Mouse, Rat, Simian
Host: Mouse
Isotype: IgG
Vial size: 0.1 mg
Concentration: 1.0 mg/ml
Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

CDKN1B protein structure - NBP2-34718-0.1 mg shown in red.